He never had children although he and Gilda Radner tried. For some reason she kept having miscarriages when doctors finally figured out she had Ovarian Cancer and died in 1989...Wilder was devastated and created a charity in her name for the pursuit of cancer cures. Gene Wilder was an awesome man and will be missed by all those who have had the pleasure of seeing his artistry over the years. Rest in peace, Gene.